发明名称 |
IL-21 AS A REGULATOR OF IMMUNOGLOBIN PRODUCTION |
摘要 |
A transgenic mouse is disclosed herein whose somatic and germ cells comprise a disrupted IL-21 receptor gene, the disruption being sufficient to inhibit the binding of IL-21 to an IL-21 receptor, and a disrupted IL-4 gene, the disruption being sufficient to inhibit the production of IL-4 or the binding of IL-4 to the IL-4 receptor. A mouse homozygous for the disrupted IL-21 receptor gene and homozygous for the disrupted IL-4 gene has diminished B cell function. A method is disclosed for altering a B cell activity. The method includes administering a therapeutically effective amount of an agent that interferes with the interaction of IL-21 with an IL-21 receptor, thereby altering the B cell activity. A method is also disclosed for of treating a subject with Job's disorder or atopic disease. A method is also disclosed for treating or preventing an allergic reaction in a subject. A method is also disclosed for treating a subject with an autoimmune or antibody mediated disorder. |
申请公布号 |
US2008166338(A1) |
申请公布日期 |
2008.07.10 |
申请号 |
US20070958540 |
申请日期 |
2007.12.18 |
申请人 |
GOV. OF THE USA, REPRESENTED BY THE SECRETARY , DEPA. |
发明人 |
LEONARD WARREN J.;OZAKI KATSUTOSHI;SPOLSKI ROSANNE;MORSE HERBERT C.;LIPSKY PETER E.;ROOPENIAN DERRY |
分类号 |
A61K39/395;A01K67/027;A61P43/00;C07K14/54;C07K14/715;C12N;C12N15/85;C12Q1/68;G01N33/53 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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