EMULSION OF PERFLUOROORGANIC COMPOUNDS FOR MEDICAL USE AND A METHODS FOR THE PREPARATION AND THE USE THEREOF

摘要

The invention relates to biomedicine. The inventive emulsion of perfluoroorganic compounds, which is used for intravascular or local injection, comprises a rapidly eliminated perfluor carbon-perfluor decalin, a low eliminated perfluorinated tertiary amine of perfluor-N-(4-methyl-cyclohexyl)-piperidine and a physiologically acceptable salt-aqueous solution. The critical solution temperatures of all components of the perfluoroorganic compounds dissolved in hexane (T<SUB>crH</SUB>) differ from each other at a value which is equal to or less than 2-4°C, thereby increasing the stability of the emulsions of perfluoroorganic compound. The emulsion of perfluoroorganic compounds is stabilised by a mixture of polyoxyethylene-polyoxypropylene block copolymers and comprises only the entirely fluorinated impurities of the perfluoroorganic compounds, thereby reducing the toxicity thereof. The inventive emulsion producing method consists in mixing and dispersing the mixture of liquid perfluoroorganic compounds with the aqueous solution of a stabilising agent and in subsequently reducing it in a high pressure homogeniser in such a way that submicron emulsion particles are obtained. The inventive method for treating the blood system diseases consists in injecting the perfluoroorganic compound emulsion into the blood current or into a lymphatic channel.