摘要 |
The application describes an assay for the identification of small molecule modulators of integrin CDl lb/CD18 and small molecules capable of modulating activity of this receptor. Such compounds may be used in certain embodiments for treating a disease or condition selected from inflammation, immune-related disorders, cancer, ischemia-reperfusion injury, stroke, neointimal thickening associated with vascular injury, bullous pemphigoid, neonatal obstructive nephropathy, and cardiovascular disease, or in other embodiments for the treatment of a disease or condition selected from immune deficiency, acquired immune deficiency syndrome (AIDS), myeloperoxidase deficiency, Wiskott-Aldrich syndrome, chronic granulomatous disease, hyper-IgM syndromes, leukocyte adhesion deficiency, Chediak-Higashi syndrome, and severe combined immunodeficiency. |
申请人 |
PARTNERS HEALTHCARE RESEARCH VENTURES & LICENSING;GUPTA, VINEET;AMIN, ARNAOUT, M. |
发明人 |
GUPTA, VINEET;AMIN, ARNAOUT, M. |