NOVEL AMINOPYRIMIDINE DERIVATIVES AS PLK1 INHIBITORS

摘要

Disclosed is a compound represented by the general formula (I) below, or a pharmaceutically acceptable salt or ester thereof. (In the formula, R1 and R2 may be the same or different and represent a hydrogen atom, a lower alky l group, a cycloalkyl group or the like; R3 and R4 may be the same or differ ent and represent a hydrogen atom, a lower alkyl group, an NRaRb, a phenyl g roup, a lower alkyl group substituted with a phenyl group, a 4- or 7-membere d aliphatic heterocyclic group, a lower alkyl group substituted with a 4- or 7-membered aliphatic heterocyclic group, a 5- or 6-membered aromatic hetero cyclic group, a lower alkyl group substituted with a 5- or 6-membered aromat ic heterocyclic group or the like; and R5 represents a hydrogen atom, a cyan o group, a halogen atom or a lower alkyl group.)