2-Propynyl adenosine analogs having A2A agonist activity and compositions thereof

摘要

The present disclosure comprises compounds and their use for the treatment of inflammatory activity in mammalian tissue. The inflammatory tissue activity can be due to pathological agents or can be due to physical, chemical or thermal trauma, or the trauma of medical procedures such as organ, tissue or cell transplantation, angioplasty (PCTA), inflammation following ischemia/reperfusion, or grafting. The present compounds of general formula (I), wherein variables shown in formula (I) are as defined in the specification, comprise a novel class of 2-alkynyladenosine derivatives, substituted at the ethyn-2-yl position by substituted cycloalkyl and heterocyclic moieties.