发明名称 |
METHOD OF IN VITRO DIFFERENTIATION OF NEURAL STEM CELLS, MOTOR NEURONS AND DOPAMINE NEURONS FROM PRIMATE EMBRYONIC STEM CELLS |
摘要 |
A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1- /Pax6+ in the presence of FGF2, FGF4, FGF8, FGF9, or RA wherein the cells are characterized by an neural tube-like rosette morphology and are Pax6+/Sox1+. ® KIPO & WIPO 2009
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申请公布号 |
KR20080109943(A) |
申请公布日期 |
2008.12.17 |
申请号 |
KR20087028900 |
申请日期 |
2008.11.26 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
ZHANG SU CHUN;THOMSON JAMES A.;DUNCAN IAN DAVID;LI XUE JUN |
分类号 |
C12N5/02;C12N;C12N5/00;C12N5/0793 |
主分类号 |
C12N5/02 |
代理机构 |
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