发明名称 |
ORAL FORMULATIONS OF GLYCYL-2-METHYLPROLYL-GLUTAMATE |
摘要 |
<p>Oral formulations of G-2MePE including microemulsions, coarse emulsions, liquid crystals, tablets and encapsulated forms of G-2MePE have improved bioavailability than conventional aqueous formulations. In particular, microparticles, nanoparticles and microemulsions can exhibit great neuroprotective effects after oral administration. In a microemulsion formulation, G-2MePE can nearly completely inhibit cerebral infarction in an animal model of stroke even after the stroke had been initiated. Thus, improved oral formulations can be desirably used to treat a variety of neurodegenerative conditions with improved convenience and improved efficacy.</p> |
申请公布号 |
EP2001400(A2) |
申请公布日期 |
2008.12.17 |
申请号 |
EP20070753175 |
申请日期 |
2007.03.14 |
申请人 |
NEUREN PHARMACEUTICALS LIMITED;WEN, JINGYUAN;THOMAS, GREGORY BRIAN;BICKERDIKE, MIKE JOHN |
发明人 |
WEN, JINGYUAN;THOMAS, GREGORY BRIAN;BICKERDIKE, MIKE JOHN |
分类号 |
A61K9/107;A61K9/28;A61K9/51;A61K38/06;A61K45/06 |
主分类号 |
A61K9/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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