发明名称 |
Ansamycins having improved pharmacological and biological properties |
摘要 |
Ansamycins and methods of preparing and using the same are described. At least some of these ansamycins exhibit one or more of improved aqueous formulation ability, chemical stability, and bioavailability. Some of the derivatives described are dimers. These and others described can include one or more solubilizing groups that have expected merit in rendering the overall compounds useful as drugs and prodrugs.
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申请公布号 |
US7465718(B2) |
申请公布日期 |
2008.12.16 |
申请号 |
US20050503880 |
申请日期 |
2005.02.22 |
申请人 |
CONFORMA THERAPEUTICS CORPORATION |
发明人 |
ZHANG LIN;LE BRAZIDEC JEAN-YVES;FRITZ LAWRENCE C.;BURROWS FRANCIS J.;BOEHM MARCUS F.;FAN JUNHUA;MCHUGH SEAN KONRAD |
分类号 |
C07D233/14;A61K31/33;A61K31/395;A61K31/397;A61K31/4025;A61K31/4192;A61K31/422;A61K31/433;A61K31/438;A61K31/4427;A61K31/4523;A61K31/4725;A61K31/496;A61K31/5377;A61K31/661;A61P9/00;A61P11/00;A61P19/02;A61P19/04;A61P25/00;A61P29/00;A61P31/04;A61P31/12;A61P31/18;A61P35/00;C07D225/06;C07D401/12;C07D403/12;C07D405/12;C07D409/04;C07D409/12;C07D413/12;C07D417/12;C07D493/04;C07F9/553 |
主分类号 |
C07D233/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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