发明名称 |
MODIFIKATION DER PROTEINGLYCOSYLIERUNG IN PICHIA PASTORIS |
摘要 |
The present invention provides genetically engineered stains of Pichia capable of producing proteins with reduced glycosylation. In particular, the genetically engineered strains of the present invention are capable of expressing either or both of an ±-1,2-mannosidase and glucosidase II. The genetically engineered strains of the present invention can be further modified such that the OCH1 gene is disrupted. Methods of producing glycoproteins with reduced glycosylation using such genetically engineered strains of Pichia are also provided. |
申请公布号 |
AT414778(T) |
申请公布日期 |
2008.12.15 |
申请号 |
AT20010955499T |
申请日期 |
2001.06.29 |
申请人 |
VIB VZW;RESEARCH CORPORATION TECHNOLOGIES, INC |
发明人 |
CONTRERAS, ROLAND;CALLEWAERT, NICO;GEYSENS, STEVEN |
分类号 |
C12N15/09;C12N15/80;A61K38/00;A61K38/46;C07K14/39;C12N1/15;C12N1/19;C12N5/10;C12N9/24;C12N15/56;C12N15/62;C12N15/81;C12P21/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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