发明名称 |
HOCHAFFINER NY-ESO-T-ZELLEN-REZEPTOR |
摘要 |
The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC SEQ NO:126 peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumour cells. The TCRs have a KD for the said peptide-HLA complex of less than or equal to 1 μM and/or have an off-rate (koff) of 1×10−3 S−1 or slower. |
申请公布号 |
AT417065(T) |
申请公布日期 |
2008.12.15 |
申请号 |
AT20050745017T |
申请日期 |
2005.05.18 |
申请人 |
MEDIGENE LTD. |
发明人 |
BOULTER, JONATHAN MICHAEL;JAKOBSEN, BENT;LI, YI;MOLLOY, PETER;DUNN, STEVEN |
分类号 |
C07K14/705;A61K38/00 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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