| 摘要 |
A recombinant vector is provided to show excellent effect on combined therapy with an anti-cancer agent by expressing an shRNA for an MDR1 and an NIS efficiently in a host cell and image position of tumor, thereby being used together with other anti-cancer agent in accordance with the purpose of treatment. A recombinant vector includes: an shRNA regarding a first promoter and an MDR1 operably linked to the first promoter; and a polynucleotide encoding a second promoter and an NIS operable linked to the second promoter. A pharmaceutical composition for treating tumor comprises the recombinant vector and an anti-cancer agent. A method for imaging tumor comprises the steps of: (a) transforming a tumor cell using the recombinant vector; (b) administering an imaging preparation into an individual; and (c) detecting the imaging preparation.
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