| 摘要 |
It is intended to provide a quickly disintegrating tablet, which has a practically appropriate tablet hardness while sustaining the disintegrability, and a process for producing the same by the direct dry-tabletting method wherein a material mixture powder before tabletting has a high flowability owing to well designed combination of an active ingredient with auxiliary ingredient(s) and, therefore, can be smoothly flown out from the hopper of a tabletting machine, no capping occurs during tabletting and the obtained tablets show little deviation in weight. Namely, a quickly disintegrating tablet produced by the direct dry-tabletting method characterized by containing (a) an active ingredient and (b)as a dissolution aid, at least one member selected from the group consisting of acid selected from among citric acid, tartaric acid, malic acid, lactic acid and ascorbic acid or alkali metal salts thereof; alkali metal hydrogencarbonates; and alkali metal carbonates, together with (c) a filler, (d) a binder, (e) a disintegrating agent, (f) a fluidizer, and (g) as a lubricant, a lubricant comprising a combination of magnesium stearate with a sucrose fatty acid ester. ® KIPO & WIPO 2009 |
