| 摘要 |
The present invention relates to the use of (a) polypeptide(s) the expression of which is indicative for hypertrophy or a heart disease or (a) nucleic acid molecule(s) encoding such (a) polypeptide(s), for the preparation of a pharmaceutical composition for the treatment or prevention of hypertrophy or a heart disease. Moreover, the present invention relates to the use of such (a) polypeptide(s) or (a) nucleic acid molecule(s) for the preparation of a diagnostic composition for detecting hypertrophy or a heart disease, as well as to methods for diagnosing hypertrophy or a heart disease or a susceptibility to hypertrophy or a heart disease. Additionally, the present invention relates to fragments and splice variants of (a) polypeptide(s) the expression of which is indicative for hypertrophy or a heart disease or (a) nucleic acid molecule(s) encoding such (a) polypeptide(s),as well as to corresponding vectors, host cells and pharmaceutical or diagnostic compositions comprising said (a) polypeptide(s), (a) nucleic acid molecule(s), vectors or host cells. Moreover, the present invention relates to a non-human transgenic animal specifically expressing in the heart a nucleic acid molecule encoding a polypeptide the expression of which is indicative for hypertrophy or a heart disease and to a corresponding nucleic acid expression construct, as well as to a corresponding vector and host cell. The present invention also relates to the use of said transgenic animal for the screening and/or validation of medicaments. |
