| 发明名称 |
V-Like Domain Binding Molecules |
| 摘要 |
The present invention relates to binding moieties comprising at least one monomeric V-like domain (VLD) derived from a non-antibody ligand, the at least one monomeric V-like domain being characterised in that at least one CDR loop structure or part thereof is modified or replaced such that the solubility of the modified VLD is improved when compared with the unmodified VLD.
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| 申请公布号 |
US2008305988(A1) |
申请公布日期 |
2008.12.11 |
| 申请号 |
US20080120733 |
申请日期 |
2008.05.15 |
| 申请人 |
COIA GREGORY;GALANIS MARIA;HUDSON PETER JOHN;IRVING ROBERT ALEXANDER;NUTTALL STEWART DOUGLAS |
发明人 |
COIA GREGORY;GALANIS MARIA;HUDSON PETER JOHN;IRVING ROBERT ALEXANDER;NUTTALL STEWART DOUGLAS |
| 分类号 |
A61K38/02;G01N33/50;A61K38/00;A61K39/395;A61P43/00;C07H21/04;C07K2/00;C07K14/665;C07K14/705;C07K14/73;C07K14/745;C07K16/00;C07K16/18;C07K16/30;C07K16/40;C12N1/21;C12N15/09;C12N15/12;C12N15/63;C12P21/02;C12Q1/70;C40B30/04;G01N33/15;G01N33/566;G01N33/68 |
主分类号 |
A61K38/02 |
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