| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for not only boosting the induction of differentiation from mesenchymal stem cells and mesenchymal cells other than osteoblast cells to the osteoblast cells, but also markedly promoting the differentiation and maturation of the osteoblast cells, and further a preventing and treating agent of the bone disorder accompanied by bone fracture and the reduction of bone mass, especially a medicine applicable to a stent device for transplantation and artificial bone prosthetic material necessary for the treatment of the broken bone and regeneration treatment in the bone disorder such as the reduction of bone mass, etc. <P>SOLUTION: This method for promoting the differentiation from the mesenchymal cells to the osteoblast cells by simultaneous use of platelet rich plasma and bone formation-inducing protein; similarly the method for promoting the differentiation and maturation of the precursor cells of the osteoblast cells and/or the osteoblast cells; the agent for preventing and treating the bone disorder accompanied by the bone fracture and the reduction of the bone mass, comprising the simultaneous use of the platelet rich plasma and bone formation-inducing protein; and the osteoblast cells used for the prevention and treatment of the bone disorder accompanied by the bone fracture and reduction of the bone mass, prepared by culturing the mesenchymal cells in the presence of the platelet rich plasma and the bone formation-inducing protein are provided. <P>COPYRIGHT: (C)2009,JPO&INPIT |
