发明名称 |
BINDING PROTEINS COMPRISING IMMUNOGLOBULIN HINGE AND FC REGIONS HAVING ALTERED FC EFFECTOR FUNCTIONS |
摘要 |
Provided herein are binding proteins comprising one or more immunoglobulin Fc region hinge, CH2, and/or CH3 domain wherein one or more hinge and/or constant region CH2 and/or CH3 domain is modified to alter the binding protein's binding affinity and/or specificity for a cognate receptor (e.g., an Fc receptor) and/or to impart one or more new binding specificity(ies) to the hinge and/or constant region that the corresponding unmodified immunoglobulin does not possess (e.g., affinity for distinct class of cognate receptor distinct from the class of cognate receptor to which the unmodified binding protein specifically binds). Binding proteins according to the present invention include, for example, modified antibodies, antibody fragments, recombinant binding proteins, and molecularly engineered binding domain-immuno globulin fusion proteins, including small modular immunopharmaceutical products (SMIP products). |
申请公布号 |
WO2007121354(A3) |
申请公布日期 |
2008.12.11 |
申请号 |
WO2007US66634 |
申请日期 |
2007.04.13 |
申请人 |
TRUBION PHARMACEUTICALS INC.;BAUM, PETER, ROBERT;ESPLING, ERIK, STEPHEN;TAN, PHILLIP;THOMPSON, PETER, ARMSTRONG |
发明人 |
BAUM, PETER, ROBERT;ESPLING, ERIK, STEPHEN;TAN, PHILLIP;THOMPSON, PETER, ARMSTRONG |
分类号 |
C07K16/00;C07K1/00;C12P21/08 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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