A SCALEABLE MANUFACTURING PROCESS FOR CYSTEINE ENDOPROTEASE B, ISOFORM 2
摘要
Methods are provided for the production of gram to kilogram quantities of pro-EP-B2 (proenzyme form of EP-B2) in a lyophilized form. The methods include scalable fermentation, refolding and purification processes, which processes may be combined with lyophilization to yield a stable product.
申请公布号
WO2008115428(A3)
申请公布日期
2008.12.11
申请号
WO2008US03425
申请日期
2008.03.14
申请人
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;VORA, HARMIT;MCINTIRE, JAMES;KUMAR, PAWAN;KHOSLA, CHAITAN
