PHENYL SUBSTITUTED CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS
摘要
Phenyl-substituted cyclohexylamine derivatives and method for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.
申请公布号
CA2688493(A1)
申请公布日期
2008.12.11
申请号
CA20082688493
申请日期
2008.06.02
申请人
SEPRACOR INC.
发明人
SHAO, LIMING;WANG, FENGJIANG;MALCOLM, SCOTT CHRISTOPHER;HEWITT, MICHAEL CHARLES;MA, JIANGUO;RIBE, SETH;VARNEY, MARK A.;CAMPBELL, UNA;ENGEL, SHARON RAE;HARDY, LARRY WENDELL;KOCH, PATRICK;SCHREIBER, RUDY;SPEAR, KERRY L.