| 摘要 |
The invention relates to compounds exhibiting immunoregulatory activity as determined by measuring the compound's ability to modulate production of NO by a cell. Preferred compounds include or consist of a sequence <tables id="TABLE-US-00001" num="00001"> <table frame="none" colsep="0" rowsep="0" tabstyle="monospace"> <tgroup align="left" colsep="0" rowsep="0" cols="3"> <colspec colname="offset" colwidth="70pt" align="left"/> <colspec colname="1" colwidth="147pt" align="left"/> <colspec colname="2" colwidth="0pt" align="left"/> <tbody valign="top"> <row> <entry/> <entry>AAL AAQ AAG AAV</entry> <entry/> </row> </tbody> </tgroup> </table> </tables> wherein AAL is a substituted or unsubstituted non-polar amino acid selected from the group consisting of Ala and Leu; wherein AAQ is a substituted or unsubstituted amino acid selected from the group consisting of Gln, Pro, and Ala; wherein AAG is a substituted or unsubstituted amino acid Gly, and wherein AAV is a substituted or unsubstituted non-polar amino acid selected from the group consisting of Val and Ala. In certain embodiments, the compound consists of a tripeptide selected from the group AQG, MTR, VVC, and mixtures thereof.
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