发明名称 |
QUINOXALINE DERIVATIVES AS INHIBITORS OF THE TYROSINE KINASE ACTIVITY OF JANUS KINASES |
摘要 |
The present invention relates to quinoxaline compound of the formula (I): wherein R1 is carbocycly! or heterocyclyl, either of which is optionally substituted with 1, 2, 3, 4 or 5 R7; R2 is carbocyclyl or heterocyclyl, either of which is optionally substituted with 1, 2, 3, 4 or 5 R8; R3, R4, R5 and R6 are each independently hydrogen or R9; and R7, R8 and R9 are each independently selected from organic and inorganic substituents, their use in therapy of diseases, in particular diseases mediated by the tyrosine kinase activity of Janus kinases, including JAK-2 and JAK-3 kinases. |
申请公布号 |
WO2008148867(A2) |
申请公布日期 |
2008.12.11 |
申请号 |
WO2008EP57058 |
申请日期 |
2008.06.06 |
申请人 |
NOVARTIS AG;GERSPACHER, MARC;FURET, PASCAL;VANGREVELINGHE, ERIC;PISSOT SOLDERMANN, CAROLE;GAUL, CHRISTOPH;HOLZER, PHILIPP |
发明人 |
GERSPACHER, MARC;FURET, PASCAL;VANGREVELINGHE, ERIC;PISSOT SOLDERMANN, CAROLE;GAUL, CHRISTOPH;HOLZER, PHILIPP |
分类号 |
A61K31/498;A61K31/5377;A61K31/541;A61P1/00;A61P3/10;A61P17/00;A61P17/06;A61P19/02;A61P21/00;A61P35/00;A61P35/02;A61P37/06;A61P41/00;A61P43/00;C07D241/42;C07D401/04;C07D401/10;C07D401/14;C07D403/04;C07D405/14 |
主分类号 |
A61K31/498 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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