| 发明名称 |
INTERNALISIERENDE ERBB2 ANTIKÖRPER |
| 摘要 |
This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalized into the cell bearing the c-erbB2 marker. Chimeric molecules comprising the F5 and/or C1 antibodies attached to one or more effector molecules are also provided. |
| 申请公布号 |
DE69939820(D1) |
申请公布日期 |
2008.12.11 |
| 申请号 |
DE1999639820 |
申请日期 |
1999.04.23 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
MARKS, JAMES D.;POUL, MARIE ALIX |
| 分类号 |
A61K39/395;C12N15/09;A61K38/00;A61K45/00;A61K47/48;A61P35/00;C07K14/01;C07K16/28;C07K16/32;C07K19/00;C12N15/86 |
主分类号 |
A61K39/395 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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