发明名称 |
Process for the crystallization of (R) - or (S) - Lansoprazole |
摘要 |
The present invention relates to a production method of a crystal of (R)-lansoprazole or (S)-lansoprazole, which includes crystallization at a temperature of about 0° C. to about 35° C. from a C1-4 alkyl acetate solution containing (R)-lansoprazole or (S)-lansoprazole at a concentration of about 0.1 g/mL to about 0.5 g/mL and the like. According to the production method of the present invention, a crystal of (R)-lansoprazole or (S)-lansoprazole superior in preservation stability can be produced efficiently on an industrial large scale.
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申请公布号 |
US2008306118(A1) |
申请公布日期 |
2008.12.11 |
申请号 |
US20070899918 |
申请日期 |
2007.09.07 |
申请人 |
TAKEDA PHARMACEUTICAL COMPANY LIMITED |
发明人 |
HASHIMOTO HIDEO;URAI TADASHI |
分类号 |
A61K31/435;A61K9/50;A61K31/44;A61P1/00;A61P1/02;A61P1/04;A61P7/04;A61P31/04;A61P35/00;C07D401/12 |
主分类号 |
A61K31/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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