ADHESIN-ENTEROTOXIN CHIMERA BASED IMMUNOGENIC COMPOSITION AGAINST ENTERTOXIGENIC ESCHERICHIA COLI
摘要
The inventive subject matter relates to an immunogenic composition composed of a chimeric molecule including a conformationally stable adhesin from Escherichia coli fused to a bacterial toxin A subunit, such as cholera toxin A subunit or heat-labile Escherichia coli toxin A subunit. The invention also relates to the adhesin-toxin chimera noncovalently associated with a toxin B subunit of the same or different species as the A subunit. The invention also relates to a method of utilizing an adhesin/toxin fusion composition to elicit an immune response.
申请公布号
WO2007114878(A3)
申请公布日期
2008.12.11
申请号
WO2007US00712
申请日期
2007.01.11
申请人
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY;SAVARINO, STEPHEN, J.;HOLMES, RANDALL, K.;JOBLING, MICHAEL, G.
发明人
SAVARINO, STEPHEN, J.;HOLMES, RANDALL, K.;JOBLING, MICHAEL, G.