IMPLANTABLE DEVICES WITH THERAPY DELIVERING SURFACES AND METHODS

摘要

An implantable device is provided having a therapy-delivering surface thereon. Upon deployment, the surface elutes a therapeutically effective dosage of dipyridamole sufficient to reduce the likelihood of thrombosis, restenosis, or both. A steady dosage of dipyridamole is delivered so as to maintain between at least about.000275 to.001 micrograms of the drug per square millimeter of tissue directly surrounding the device for a target therapy period. The device can be a cardiovascular stent in which the therapy is applied during at least the initial 7 days after deployment.