发明名称 |
REGULATION OF NEUROTRANSMITTERS SEQUESTRATION AND RELEASE THROUGH MANIPULATION OF THE VESICULAR FUNCTIONS |
摘要 |
A method of selecting an agent comprising a neuroprotecting activity is disclosed. The method comprises: (a) introducing a plurality of agents into a plurality of cells; and (b) analyzing Vesicular Monoamine Transporter 2 (VMAT2) transcription in the cells; and (c) identifying an agent of the plurality of agents capable of up-regulating DJ-1-dependent VMAT2 transcription in the cells, thereby selecting the agent comprising the neuroprotecting activity. |
申请公布号 |
WO2008111063(A3) |
申请公布日期 |
2008.12.11 |
申请号 |
WO2008IL00336 |
申请日期 |
2008.03.12 |
申请人 |
RAMOT AT TEL AVIV UNIVERSITY LTD.;LEV, NIRIT;OFFEN, DANIEL;MELAMED, ELDAD |
发明人 |
LEV, NIRIT;OFFEN, DANIEL;MELAMED, ELDAD |
分类号 |
G01N33/50;A61P25/16;C12Q1/68 |
主分类号 |
G01N33/50 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|