INDUCTION OF TOLEROGENIC PHENOTYPE IN MATURE DENDRITIC CELLS
摘要
The present invention relates to the use of a CD45 binding molecule to mo dulate the function of Dendritic cells. In particular the present invention relates to the use of a CD45 binding molecule to induce tolerogenic dendriti c cells, useful in the treatment of diseases or disorders such as autoimmune diseases, transplant rejection.
申请公布号
CA2689570(A1)
申请公布日期
2008.12.11
申请号
CA20082689570
申请日期
2008.06.03
申请人
NOVARTIS AG;FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR
发明人
GREGORI, SILVIA ADRIANA;RONCAROLO, MARIA GRAZIA;CARBALLIDO HERRERA, JOSE M.;DE VRIES, JAN E.;KORTHAEUER, ULF