发明名称 |
ILLUDIN ANALOGS USEFUL AS ANTITUMOR AGENTS |
摘要 |
The present invention provides illudin analogs of the general formula (I): where R1 is (CH2)n-X-Y or H; n is 0 to 4; X is O or S or N or absent; and Y is an optionally substituted (C1-C8)alkyl, (C6-C10)aryl, (C6-C10)aryl(C1-C4)alkyl or cyclo(C3-C6)alkyl optionally comprising one or more heteroatoms; a monosaccharide, an amino acid residue, or H when n is 2-4; R2 is absent; or R1 and R2 together comprise a 5-7 membered cyclic ring; R3 is (C1-C4)alkyl or H; R4 is H, SCH2CO2(C1-C4)alkyl, O-(C5-C12)aryl or -S-(C5-C12)aryl; R5 is H, OH or absent; R6 is (C1-C4)alkyl or absent; R7 is OH or OSi((C1-C4)alkyl)3; or R6 and R7 together are ethylenedioxy; R8 is optionally substituted (C1-C4)alkyl; and the bonds represented by --- are individually present or absent. The invention further provides dimers comprising analogs of formula (I).
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申请公布号 |
US2008306013(A1) |
申请公布日期 |
2008.12.11 |
申请号 |
US20070955247 |
申请日期 |
2007.12.12 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
MCMORRIS TREVOR C.;KELNER MICHAEL J. |
分类号 |
A61K31/122;C07D233/64;A61K9/08;A61K9/48;A61K31/19;A61K31/215;A61K31/357;A61K31/36;A61K31/4164;A61K31/695;A61K31/7028;A61P35/00;A61P35/04;C07C35/37;C07C39/17;C07C49/727;C07C49/737;C07C49/743;C07C49/753;C07C49/755;C07C49/757;C07C59/90;C07C69/007;C07C69/16;C07C69/96;C07C205/45;C07C323/22;C07C323/52;C07C323/58;C07D233/54;C07D317/72;C07D319/08;C07F7/18;C07H15/18 |
主分类号 |
A61K31/122 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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