Novel Hansenula Polymorpha Gene Coding for Alpha 1,6-Mannosyltransferase and Process for the Production of Recombinant Glycoproteins with Hansenula Polymorpha Mutant Strain Deficient in the Same Gene

摘要

Disclosed are a novel Hansenula polymorpha gene coding for alpha-1,6-mannosyltransferase initiating outer chain elongation in N-linked glycosylation, an H. polymorpha mutant strain having a deficiency in the gene, and a process for producing recombinant glycoprotein using such a mutant strain.