Aseptic-anopheles-species insects, aseptic plasmodium-species sporozoites obtained therefrom and a vaccine comprising aseptic plasmodium-species sporozoites

摘要

Disclosed are production of Plasmodium species sporozoites in Anopheles species mosquitoes, specifically; apparatuses and methods for the production of strains of haematophagous insects with desired properties such as hypoallergenicity or hyperinfectivity; methods of producing a parasite strain that is capable of withstanding cyropreservation at temperatures close to freezing; apparatuses and methods for the injection of an attenuated parasite vaccine; production of parasites and haematophagous insects that are free from contamination by unwanted biological agents.