| 摘要 |
FIELD: medicine; oncology. ^ SUBSTANCE: determine clinical symptoms and risk factors from the anamnesis of life and clinico-laboratory indicators, namely indicators: age, level of prostates-specific of an antigen in blood serum (BSA), degree of differentiation of a tumour, duration of disease prior to the beginning of treatment on which sizes carry out the prognosis. In addition perform an estimation of the general condition of the patient on the ECOG scale and establish gradation and numerical value of risk factors. Then define prognostic factors F1 and F2 under formulas: F1=-0.68-0.5bullX1+0.13bullX2+0.93bullX3+0.62bullX4; F2=-2.97+1.17bullX1-0.3bullX2-2.17bullX3-1.45bullX4; and at F1 is more than F2, life expectancy of the patient in months (yF2 define under the formula: yF1=0.29bullX5-2.12bullX2+0.56bullX1+1.86bullX3-0.02bullX1 2+0.0006bullX4 2, and at F2 is more than F1, life expectancy of the patient in months (yF2) define under the formula: yF2=160.19-0.94bullX5-17.00bullX2-0.36bullX1, where X1.2...5 - gradation and numerical value of risk factors, Thereat, X1 - duration of disease - time from occurrence of symptoms of disease to the reference of the patient to the doctor, in months; X2 - a tumour differentiation: G0 - highly differentiated tumour=0, G1 - differentiated tumour=1, G2 - is moderate-differentiated tumour=2, G3 - low-grade tumour=3, G4 undifferentiated tumour=4; X3 - the general condition of the patient on the ECOG scale: activity of the patient is unlimited=0, restriction by kinds of the activity, demanding efforts=1, walking and capable itself to serve, but incapable to carry out any job=2, is limited capability for self-service=3, are completely incapable to any kind of activity=4; X4 - level of the BSA in ng/ml, X5 - age, years. ^ EFFECT: increase of accuracy of the prognosis at the expense of definition of life expectancy of patients in months, and it is simple in execution. ^ 4 ex |
