发明名称 |
PROMOTER MUTATIONS THAT INCREASE AMYLOID PRECURSOR PROTEIN EXPRESSION |
摘要 |
<p>The present invention relates to mutations in the amyloid precursor protein (APP) promoter region, whereby the mutations cause a significant increase in APP expression. The increase in APP expression is related to Alzheimer's disease, and the mutations can be used in Alzheimer's disease diagnosis, or in the construction of transgenic animal models for studying Alzheimer's disease.</p> |
申请公布号 |
EP1999144(A1) |
申请公布日期 |
2008.12.10 |
申请号 |
EP20070726803 |
申请日期 |
2007.03.12 |
申请人 |
VIB VZW;UNIVERSITEIT ANTWERPEN |
发明人 |
VAN BROECKHOVEN, CHRISTINE;THEUNS, JESSIE |
分类号 |
C07K14/47;A01K67/027;C12N15/09 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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