| 摘要 |
Compounds of formula (I) wherein R1 and R2, independently, are hydrogen (C1-4)alkyl, (C1-4)alkoxy, (C1-4)alkylthio, halogen, trifluoromethyl, trifluoromethoxy, cyano, (C2-5)alkanoyl, (C1-4)alkylsulfonyl or sulfamoyl; R3 is hydrogen, hydroxy, (C1-4)alkyl, (C1-4)alkoxy, halogen, cyano, (C2-5)alkanoyl, carbamoyl, (C1-4)alkylsulfonyloxy or trifluoromethylsulfonyloxy; and R4 and R5, independently, are hydrogen, (C1-4)alkyl, hydroxy(C2-4)alkyl or phenyl(C1-4)alkyl, or form together with the nitrogen atom to which they are attached a pyrrolidinyl, piperidino or piperazinyl group, in free base or acid addition salt form. Compounds according to formula (1) are useful in the treatment of epilepsy, stroke and brain or spinal trauma.
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