发明名称 |
Thiazole and oxazole VDAC regulator |
摘要 |
The present invention provides a VDAC regulator comprising a compound represented by the formula (I): wherein R1 is a halogen atom, an optionally substituted heterocyclic group, an optionally substituted hydroxyl group, an optionally substituted thiol group or an optionally substituted amino group; A is an optionally substituted acyl group, an optionally substituted heterocyclic group, an optionally substituted hydroxyl group or an optionally esterified or amidated carboxyl group; B is an optionally substituted aromatic group; X is an oxygen atom, a sulfur atom or an optionally substituted nitrogen atom; and Y is a divalent hydrocarbon group or heterocyclic group; a salt thereof or a prodrug thereof, which is useful as an agent for the prophylaxis or treatment of Down's syndrome and the like.
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申请公布号 |
US7462635(B2) |
申请公布日期 |
2008.12.09 |
申请号 |
US20040507731 |
申请日期 |
2004.09.14 |
申请人 |
TAKEDA PHARMACEUTICAL COMPANY LIMITED;TOKYO INSTITUTE OF TECHNOLOGY |
发明人 |
SUGIYAMA YASUO;HAZAMA MASATOSHI;IWAKAMI NORIHISA |
分类号 |
A61K31/422;A61K31/4178;A61K31/427;A61P1/00;A61P1/16;A61P3/04;A61P3/06;A61P3/10;A61P7/06;A61P9/00;A61P9/10;A61P9/12;A61P19/02;A61P21/00;A61P25/00;A61P25/04;A61P25/08;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P27/02;A61P31/18;A61P31/20;A61P43/00;C07D263/34;C07D413/04;C07D413/14 |
主分类号 |
A61K31/422 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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