| 摘要 |
<p>Dry granulation process for manufacturing a pharmaceutical composition having uniform drug distribution and potency, comprising blending silicon dioxide and at least one pharmaceutically acceptable excipient, carrier or diluent in a high shear granulator for an appropriate amount of time to produce a blended mixture, adding and active ingredient to the granulator and blending for an additional period of time to form an active blend, transferring the active blend from the granulator to a blender, optionally adding one or more additional pharmaceutically acceptable excipients, carriers or diluents to the active blend, and blending for a suitable period of time to form a pharmaceutical composition having uniform distribution of the active ingredient and uniform potency, wherein the active ingredient is a compound of the general formula (I), in which: E and B represent CH and N, R1 is hydrogen, hydroxy, fluorine or chlorine group and is group specified in description.</p> |
