The invention relates to a method of identifying a modulator of RHBDL4, said method comprising (i) providing a first and second sample of cells; (ii) contacting said first sample of cells with a candidate modulator of RHBDL4; (iii) measuring epidermal growth factor receptor (EGFR) transactivation in said first and second samples of cells, wherein a difference between the transactivation measured in said first and second samples of cells identifies said candidate modulator of RHBDL4 as a modulator of RHBDL4. The invention also relates to RHBDL4 protease assays and to uses of RHBDL4 protease and methods of cleavage of RHBDL4 substrates.
申请公布号
WO2008125836(A3)
申请公布日期
2008.12.04
申请号
WO2008GB01295
申请日期
2008.04.11
申请人
MEDICAL RESEARCH COUNCIL;LEMBERG, MARIUS, KASPER;FREEMAN, MATTHEW