MECHANISM OF ASTRICYTE-NEURON SIGNALING

摘要

The present invention relates to a novel communication mechanism between astrocytes and neurons at a synapse. More specifically, the present invention relates to a signaling mechanism between astrocytes and neurons, by activating astrocytic G-protein coupled receptors, thereby activating glutamate receptors on a membrane of neighboring postsynaptic neurons, resulting in increasing the level of intracellular Ca2+ and inducing a depolarization inward current to control neurotransmission in neurons.