VECTORS FOR INDUCING HOMOZYGOUS MUTATIONS AND METHODS OF USING SAME

摘要

The present invention provides vectors for inducing homozygous mutations in cells. Also provided are cells and populations of cells comprising a vector of the present invention. Further provided are methods of identifying cells with homozygous mutations. Also provided are methods of identifying agents that increase the frequency of homozygous mutations in cells. The present invention also provides methods of identifying a gene that is responsible for a recessive genetic trait.