CHELATION OF METALS TO THIOL GROUPS USING IN SITU REDUCTION OF DISULFIDE-CONTAINING COMPOUNDS BY PHOSPHINES
摘要
A method is disclosed for the syntheses of thiol-containing radiopharmaceuticals without the need for purification starting from chelators containing disulfide bonds. This is done by providing a method that reduces disulfide bonds on a precursor molecule or a precursor compound in the presence of phosphine compounds, thus freeing thiols for metal complexation.
申请公布号
WO2007109475(A3)
申请公布日期
2008.12.04
申请号
WO2007US63973
申请日期
2007.03.14
申请人
BRACCO IMAGING S.P.A.;LINDER, KAREN, E.;CAGNOLINI, ALDO;FAN, HONG (HELEN);RAMALINGAM, KONDAREDDIAR
发明人
LINDER, KAREN, E.;CAGNOLINI, ALDO;FAN, HONG (HELEN);RAMALINGAM, KONDAREDDIAR