METHODS AND COMPOSITIONS FOR ENHANCING PROTEASOME ACTIVITY
摘要
<p>This invention relates to methods and compositions for enhancing proteasome activity in a cell. The methods and compositions for enhancing the activity of the proteasome in cells modulate the activity of Ubp6 (yeast) or Uspl4 (human), an endogenous inhibitor of the proteasome. The methods and compositions partially or completely reduce the inhibitory activity of Uspl4 on a proteasome, thereby specifically enhancing the protein-degradation activity of the proteasome. The invention also provides methods of screening to identify inhibitors of Ubp6, Uspl4, and/or both Ubp6 and Uspl4.</p>
申请公布号
WO2008147536(A1)
申请公布日期
2008.12.04
申请号
WO2008US06621
申请日期
2008.05.23
申请人
PRESIDENT AND FELLOWS FOR HARVARD COLLEGE;FINLEY, DANIEL;HANNA, JOHN;HATHAWAY, NATHANIEL;KING, RANDALL;LEE, BYUNG-HOON