TRIAZOLE DERIVATIVES FOR T-TYPE CALCIUM CHANNEL BLOCKER

摘要

A triazole derivative useful as a T-type calcium channel blocker, and a pharmaceutical composition containing the derivative rae provided to inhibit the calcium channel of cell membranes, thereby preventing and treating the diseases such as brain disease, heart disease, neurogenic pain and cancer disease. A triazole derivative is represented by the formula 1, wherein R1 is phenyl group, a benzimidazole group, or a benzimidazole C1-C8 alkyl group; R2 is H, a C1-C8 alkyl group, a C1-C20 alkanoyl group, a phenyl group, a benzoyl group, or a thiophenecarbonyl group; R3 is H, or an N-phenylacetamide group; and the benzene ring of a phenyl group, a benzoyl group, a benzimidazole group and an N-phenylacetamide group can be substituted with 1-4 substituents selected from a halogen atom, a nitro group, a C1-C8 alkyl group, a C1-C8 alkoxy group and a C1-C8 haloalkyl group.