摘要 |
<p>The present invention relates to new selective 5HT6 receptor binding benzofuran derivatives of general formula (I) wherein, Z represents a hydrogen atom, C1-4 acyl group, C1-6 alkyl sulfonyl group, phenyl sulfonyl group substituted with one or more halogen atom; or naphthyl sulfonyl group optionally substituted with a halogen atom, tetrahydro naphthyl sulfonyl group, (lS)(+)-10-camphor-sulfonyl group, (lR)(-)-10-camphor-sulfonyl group or benzofuranyl sulfonyl group, substituted with a halogen atom and C1 -4 alkyl group, Y represents C2-6 alkylene group, R1 and R2 represent, independently, a hydrogen atom, C1-4 alkyl group, benzyl group, or together with one or more halogen atoms, trifluoromethyl group, or C1-4 alkoxy group substituted 4-phenyl-piperazine-l-yl group; and/or their pharmaceutically suitable acid addition salts, to the process for producing said compounds, to pharmaceutical compositions containing said compounds and to their use in treatment and/or prevention of disorders of the central nervous system and cardiovascular system.</p> |
申请人 |
EGIS GYOGYSZERGYAR NYILVANOSAN MUEKOEDOE RESZVENYTARSAGAG;RIVO, ENDRE;PRAUDA, IBOLYA;REITER, JOZSEF;BARKOCZY, JOZSEF;GACSALYI, ISTVAN;KOMPAGNE, HAJNALKA;SZIRAY, NORA;PALLAGI, KATALIN;EGYED, ANDRAS;HEGEDUES, ENDRE;LEVAY, GYOERGY;HARSING, LASZLO GABOR |
发明人 |
RIVO, ENDRE;PRAUDA, IBOLYA;REITER, JOZSEF;BARKOCZY, JOZSEF;GACSALYI, ISTVAN;KOMPAGNE, HAJNALKA;SZIRAY, NORA;PALLAGI, KATALIN;EGYED, ANDRAS;HEGEDUES, ENDRE;LEVAY, GYOERGY;HARSING, LASZLO GABOR |