METHODS FOR TREATING CANCER RESISTANT TO ERBB THERAPEUTICS
摘要
Provided herein are methods for treating cancer that is resistant to treatment with an anti- ErbB therapeutic agent and which is associated with an activating MET gene mutation or a MET gene amplification. The methods involve administering to a subject a combination of an anti- ErbB therapeutic and an anti-MET therapeutic. Also provided are methods for reducing ErbB mediated signaling or PI3 kinase mediated signaling in a cancer cell.
申请公布号
WO2008127710(A3)
申请公布日期
2008.12.04
申请号
WO2008US04804
申请日期
2008.04.11
申请人
DANA FARBER CANCER INSTITUTE;BETH ISRAEL DEACONESS MEDICAL CENTER;MASSACHUSETTS GENERAL HOSPITAL;JANNE, PASI, A.;ENGELMAN, JEFFREY;CANTLEY, LEWIS, C.
发明人
JANNE, PASI, A.;ENGELMAN, JEFFREY;CANTLEY, LEWIS, C.