| 摘要 |
The invention relates to a process for the optical resolution of a dibenz o[b,d]azepinone derivative of the formula (II) wherein R1 is hydrogen or hal ogen and R2 has the meaning of C1- 4-alkyl optionally substituted with C3-7- cycloalkyl or benzyl which is optionally substituted with C1-4-alkoxy to obt ain a (S)-7-amino-5H,7H-dibenzo[b,d]azepin-6-one of the formula (I) wherein R1 is as above. The (S)-7-amino-5H,7H-dibenzo[b,d]azepin-6-ones of formula ( I) can be used as chiral building blocks for the preparation of malonamide d erivatives which have the potential to act as .gamma.-secretase inhibitors a nd therefore may be useful in the treatment of Alzheimer's disease and cance r.
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