| 摘要 |
[00267] The present invention relates to methodsof identifying a disease treatable with PARP modulators by identifying a level of PARP in a sample of a subject, making a decision regarding identifying the disease treatable by the PARP modulators wherein the decision is made based on the level of PARP . The method further comprises of treating the disease in the subject with t he PARP modulators. The methods relate to identifying up-regulated PARP in a disease and making a decision regarding the treatment of the disease with P ARP inhibitors. The extent of PARP up-regulation in a disease can also help in determining the efficacy of the treatement with PARP inhibitors. [00268] The present invention discloses various diseases that have up-regulated or d own-regulated PARP and can be treated with PARP inhibitors or PARP activator s, respectively. The examples of the diseases include cancer, inflammation, metabolic disease, CVS disease, CNS disease, disorder of hematolymphoid syst em, disorder of endocrine and neuroendocrine, disorder of urinary tract, dis order of respiratory system, disorder of female reproductive system, and dis order of male reproductive system.
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