MODULATION OF NITRIC OXIDE SIGNALING TO NORMALIZE TUMOR VASCULATURE
摘要
The instant invention provides methods for treating a solid tumor in a subject comprising modulating nitric oxide production in the tumor to normalize tumor vasculature and administering an anti-tumor therapy to the subject. The invention further provides methods of treating a solid tumor in a subject comprising selectively increasing cyclic guanosine monophosphate (cGMP) or cGMP dependent protein kinase G production in the tumor vasculature to an amount effective to normalize tumor vasculature and administering an anti-tumor therapy to the subject.
申请公布号
WO2008100591(A3)
申请公布日期
2008.12.04
申请号
WO2008US02004
申请日期
2008.02.14
申请人
THE GENERAL HOSPITAL CORPORATION;JAIN, RAKESH, K.;FUKUMARA, DAI;KASHIWAGI, SATOSHI