发明名称 |
IMPROVED PROCESSES FOR MAKING HYDRAZIDES |
摘要 |
A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continuously to said slurry. The method avoids or limits production of undesired bis-hydrazide by-products. The method is used to prepare 3-methyl-3-mercaptobutanoic acid hydrazide, a molecule used to link calicheamicin to a monoclonal antibody. |
申请公布号 |
WO2008147765(A1) |
申请公布日期 |
2008.12.04 |
申请号 |
WO2008US64213 |
申请日期 |
2008.05.20 |
申请人 |
WYETH;CHIARELLO, GEORGE A.;SAHLI, AYMAN |
发明人 |
CHIARELLO, GEORGE A.;SAHLI, AYMAN |
分类号 |
A61K47/48;C07C241/04;C07C243/28;C07C323/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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