LINCOSAMIDE DERIVATIVE, AND ANTIBACTERIAL AGENT COMPRISING THE SAME AS ACTIVE INGREDIENT

摘要

Disclosed is a compound represented by the formula (I) or a pharmacologically acceptable salt or solvate thereof [in the formula (I), A represents an aryl group and R1 represents a 5- or 6-membered monocyclic heterocyclic group, or A represents a 4- to 6-membered monocyclic heterocyclic group and R1 represents an aryl group or 5- or 6-membered monocyclic heterocyclic group; R2 represents a hydrogen atom or a C1-6 alkyl group; R3 represents a C1-6 alkyl group or a (C3-6 cycloalkyl)-(C1-4 alkyl) group; R4, R5 and R6 independently represent a hydrogen atom; R7 represents a C1-6 alkyl group; and m represents a number of 1 to 3]. The compound is a novel lincosamide derivative having a potent activity against a drug-resistant Streptococcus pneumoniae bacterium. The compound can be used as an antibacterial ingredient, and is useful for the prevention or treatment of a bacterium-mediated infectious disease.