发明名称 |
High avidity polyvalent and polyspecific reagents |
摘要 |
<p>This application provides polyvalent or polyspecific protein complexes, comprising three or more polypeptides which associate to form three or more functional target-binding regions (TBRs), and in which each individual polypeptide comprises two or more immunoglobulin-like domains which are covalently joined together, such that two Ig-like domains in a single polypeptide do not associate with each other to form a TBR. By using a linker peptide of fewer than three amino acid residues the immunoglobulin-like domains of the individual polypeptides are prevented from associating, so that complex formation between polypeptides is favoured. Preferably the polyvalent or polyspecific protein is a trimer or tetramer. The proteins of the application have specifities which may be the same or different, and are suitable for use as therapeutic, diagnostic or imaging agents.</p> |
申请公布号 |
EP1997514(A1) |
申请公布日期 |
2008.12.03 |
申请号 |
EP20080015462 |
申请日期 |
1998.03.26 |
申请人 |
AVIPEP PTY LIMITED |
发明人 |
HUDSON, PETER JOHN;KORTT, ALEX ANDREW;IRVING, ROBERT ALEXANDER;ATWELL, JOHN LESLIE |
分类号 |
A61K47/48;C12N15/09;A61K38/00;A61K39/395;A61K51/00;C07K14/705;C07K16/00;C07K16/10;C07K16/40;C07K16/42;C12N15/13 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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