A crystal structure of the ErbB4 kinase domain (ErbB4K), specifically the ErbB4K in liganded form as well as methods of using the same in the discovery of ErbB4 inhibitors. Disclosed further are methods of treatment of diseases mediated by inappropriate ErbB4 activity utilizing ErbB4 inhibitors identified by the methods disclosed herein.
申请公布号
EP1585480(A4)
申请公布日期
2008.12.03
申请号
EP20040703575
申请日期
2004.01.20
申请人
SMITHKLINE BEECHAM CORPORATION
发明人
SHEWCHUK, LISA MARIE;HASSELL, ANNE MOORE;BRIGNOLA, PERRY, SCOTT