发明名称 |
OLIGONUCLEOTIDES COMPRISING ALTERNATING SEGMENTS AND USES THEREOF |
摘要 |
<p>The invention relates to oligonucleosides having alternating segments of sugar-modified nucleosides and 2′-deoxynucleosides, and uses thereof. The invention further relates to oligonucleotides having alternating segments of sugar-modified nucleotides and 2′-deoxynucleotides, and uses thereof. Such uses include the preparation of antisense oligonucleotides and their use for the prevention or depletion of function of a target nucleic acid of interest, such as an RNA, in a system. Accordingly, an oligonucleotide of the invention is useful for therapeutic, analytical and diagnostic methods and uses, as well as a component of compositions and commercial packages corresponding to such methods and uses.</p> |
申请公布号 |
EP1470144(B1) |
申请公布日期 |
2008.12.03 |
申请号 |
EP20030700774 |
申请日期 |
2003.01.31 |
申请人 |
MCGILL UNIVERSITY |
发明人 |
DAMHA, MASAD, J.;PARNIAK, MICHAEL, A. |
分类号 |
C07H21/00;C12N15/09;A61K31/7088;A61K31/712;A61K38/00;A61K48/00;A61P1/16;A61P3/10;A61P9/10;A61P29/00;A61P31/12;A61P31/18;A61P31/20;A61P35/00;C07H21/02;C12N15/113;C12Q1/68;C12Q1/70 |
主分类号 |
C07H21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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